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. 2017 Dec 17;103(3):540–549. doi: 10.3324/haematol.2017.176974

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Figure 2. — Variably defective Ca²⁺ entry in platelets from patients with ORAI1^W/W, ORAI1^G/S or STIM1^R/C mutations. Fura-2-loaded platelets in Hepes buffer with 0.1 mM EGTA were stimulated with thapsigargin (1.0 μM), and after a defined time with CaCl₂ (2 mM). Platelets were analyzed from 12 healthy home controls (HC1-12), 6 healthy travel controls (C1-6), and the indicated patients/relatives (P1-6). Platelets from patient P1 were also analyzed after bone marrow (BM) transplantation. Shown are maximal increases in Ca²⁺. Dotted lines indicate range of store-operated Ca²⁺ entry (SOCE) levels (CaCl₂-induced Ca²⁺ rise after thapsigargin) for platelets from home controls (mean ± SD, for HC1-12).