Figure 4. Suppression of SST IN activity reduces evoked LLD magnitude.

A, example traces of membrane hyperpolarization induced by light activation of Arch (left) and superimposed traces showing SST cell responses to a depolarizing current injection with and without light activation (right). The SST IN was hyperpolarized by illumination and AP initiation blocked. B, superimposed traces of electrically evoked activity recorded from a PYR (top) and IN (bottom) with or without concurrent slice illumination in control aCSF (left) and after 4AP + EAA blockers wash‐on (right). Arrows indicate the time of stimulation. C, light inactivation of SST INs significantly reduced the amplitude, duration and AUC of evoked LLDs. ^* P < 0.05, Tukey's post hoc test. Bars indicate the timing and duration of light pulses. Each shape represents an individual cell. Error bars are the mean ± SEM. [Color figure can be viewed at wileyonlinelibrary.com]