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. 2018 Jan 24;596(5):901–919. doi: 10.1113/JP275317

Figure 8. Suppression of VIP IN activity minimally alters evoked LLD magnitude.

Figure 8

A, example traces of membrane hyperpolarization induced by light activation of Arch (top) and superimposed traces showing VIP cell response to a depolarizing current pulse with and without Arch activation (bottom). Light activation hyperpolarized the VIP IN and blocked AP generation. B, superimposed traces from a PYR cell comparing electrically evoked activity recorded with and without concurrent light illumination in the presence of 4AP + EAA blockers. Arrow indicates the time of stimulation. C, light inactivation of VIP INs significantly reduced only the AUC of evoked LLDs in PYRs. * P < 0.05, Tukey's post hoc test test. Blue bars indicate the timing and duration of light pulses. Each shape represents an individual cell. Error bars are the mean ± SEM. [Color figure can be viewed at wileyonlinelibrary.com]