Fig. 2.
Genomic regions putatively under positive selection in sheep. a Population differentiation (FST) and relative nucleotide diversity between wild and domestic sheep (πmouflon/πdomestic) was estimated in 20 kb genomic bins. A total of 1420 outlier bins exhibiting evidence for selection in domestic sheep genomes are indicated in red (corresponding to Z-test P < 0.001, where FST > 0.156 and ln ratio >0.672). b Genome-wide distribution of relative nucleotide diversity. Positive values identify genomic bins with depressed diversity in domestic sheep compared with mouflon, consistent with positive selection sweeps involved with domestication and selection (Table 1, Supplementary Table 4). c Selective sweeps located either side of KITLG coding exons. Integrated Genome Visualisation (IGV) screenshot of chromosome 3:124236035–125400001 illustrates the reduction of SNP variation in 67 domestic genomes compared with 17 Mouflon. The two regions identified by our selection metrics are shown inside the dashed red boxes