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. 2018 Feb 28;8:3817. doi: 10.1038/s41598-018-22010-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Sciatic nerves of P4 mir-138-1 cKO mice appear to be morphologically similar to the controls. (A) Semi-thin cross sections of P4 mir-138-1 cKO and control sciatic nerves stained with Toluidine blue. In both mutants and controls, normal numbers of myelin sheaths are observed in the nerves. (B) Electron microscopic analyses of P4 mir-138-1 cKO and control sciatic nerves in cross sections. In both mutants and controls, myelinating SC are mainly observed. (C) Percentage (%) of axons in axon diameter ranges (μm). There is no significant difference in axon diameter distribution in P4 control and mir-138-1 cKO nerves. (D) Scatter plot of g-ratio (axon diameter/fiber diameter) versus axon diameter. There is no significant difference in the relationship between axon diameter and myelin thickness in P4 control and mir-138-1 cKO nerves. (E) Box-and-whisker plot of g-ratios measured from the P4 control and mir-138-1 cKO axons. >400 axons were measured in each sample. (F) Percentage (%) of axons in g-ratios ranges. There is no significant difference in myelin thickness distribution between P4 mir-138-1 cKO and control nerves. N = 3 in (A–F).