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. 2018 Feb 28;8:3798. doi: 10.1038/s41598-018-22047-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Myelinated axons in the auditory pathway. (A) Representative sagittal brainstem section of the trapezoid body fiber tract (see insert). Anti-neurofilament light chain (NFL, red) antibodies label all axons. The major structural myelin protein, myelin basic protein (MBP) labels myelin sheaths (green) and nuclei are labeled with DAPI (blue). Distinct transverse fiber bundles are shown, cut in cross-section. The arrowhead and arrow show small (1 μm) and large (5 μm) diameter transverse fibers. (B) Proportion of myelinated fibers traversing the trapezoid body tract in (Ba) Cldn11^+/−::Tg^+/− and (Bb) Cldn11^−/−::Tg^+/− mice. We quantified fibers from a single sagittal section/mouse (−), which was medial to MNTB principal neuron cell bodies in the calyx of Held and included contralateral afferents from the cochlear nucleus. We also quantified fibers from 3 sections/mouse, spaced 50 μm apart (+), within the MNTB and included calyx of Held principal neuron cell bodies. Data plotted as mean ± SEM; n = 3 fields/slide totaling ~150 axons. Scale bars, 20 μm. Insert in A: Image Credit, Allen Institute.