Figure 3.

Effect of PGE₂ in inducing IL-23 production in DCs. Transwell co-cultures were set up as above in the absence (none; vehicle control) or the presence of (a) COXs inhibitors (SC560, 100 nM, or indomethacin, 100 nM) or (b) PGE₂ receptor antagonists (AH6809, 10 uM, and AH23848, 10 uM). Data given as the means ± SE from three-five independent experiments performed with DCs from different donors. Mann-Whitney U test was used and for pair-wise comparisons only. *p < 0.05, **p < 0.01.