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. 2018 Feb 28;38(9):2283–2293. doi: 10.1523/JNEUROSCI.2304-17.2018

Figure 5.

Figure 5.

Response of GnRH neurons from PNA mice to acute GABA application is blunted at 3 weeks of age. A, Whole-cell voltage-clamp recording of current response to GABA in a GnRH neuron from an adult control female. B–E, Representative on-cell recordings of firing response (vertical action currents) to GABA in cells from adult control (B), adult PNA (C), 3-week-old control (D), and 3-week-old PNA female (E) mice. A–E are on the same time scale. F, Percentage of GnRH neurons that fire in response to GABA. The number of cells studied is shown within each bar (Fisher's exact test for each age group, *p < 0.05). G, Individual values (circles) and mean ± SEM (crosses) of the magnitude of GABA-induced membrane depolarization (two-way ANOVA/Fisher's LSD; sex/treatment, F(1,56) = 2.3; age, F(3,56) = 2.4; interaction, F(3,56) = 2.1).