Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Feb 14;8(2):170253. doi: 10.1098/rsob.170253

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2018 The Authors.

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

PMC Copyright notice

Figure 7. — A proposed network controlling STIL abundance. According to this model, cytoplasmic STIL is degraded by SCF-βTrCP throughout interphase, while centrosome-associated STIL is protected, possibly through CPAP. CDK2 activity antagonizes SCF-βTrCP-mediated STIL degradation and additionally, may cooperate with PLK4 to enhance STIL recruitment to centrioles. During progression through M phase, the combined action of CDK1 and APC/C then results in STIL release from centrioles and cytoplasmic degradation, respectively [39].