Table 6. Logistic regression analyses for autoantibodies in patients with Crohn’s disease.
Coefficient | Std.Error | Odds ratio | 95% CI | P Value | |
---|---|---|---|---|---|
B3 | |||||
IgG aGP2 | 0.005 | 0.002 | 1.005 | 1.002, 1.009 | 0.0044 |
Gender | 0.978 | 0.430 | 2.660 | 1.144, 6.184 | 0.0230 |
Severe disease | |||||
IgG aGP2 | 0.011 | 0.003 | 1.012 | 1.005, 1.018 | 0.0002 |
IgG ASCA | −0.035 | 0.020 | 0.965 | 0.928, 1.005 | 0.0822 |
Age | 0.053 | 0.022 | 1.055 | 1.011, 1.100 | 0.0134 |
Duration | −0.126 | 0.061 | 0.881 | 0.781, 0.994 | 0.0397 |
Steroids response | |||||
IgG ASCA | 0.015 | 0.008 | 1.016 | 1.001, 1.031 | 0.0426 |
5-ASA | 1.168 | 0.364 | 3.215 | 1.574, 6.566 | 0.0013 |
B2 | −0.592 | 0.355 | 0.553 | 0.276, 1.109 | 0.0953 |
Duration | −0.088 | 0.034 | 0.915 | 0.857, 0.978 | 0.0083 |
Dermatologic | |||||
IgA ASCA | 0.008 | 0.004 | 1.008 | 1.000, 1.016 | 0.0461 |
Anti-TNF | −1.307 | 0.517 | 0.271 | 0.098, 0.746 | 0.0116 |
B represents disease behavior (B2, stricturing; B3, penetrating; p, perianal disease modifier) based on the Montreal Classification. 5-ASA, therapy with 5-aminosalicylic acid; aGP2, anti-zymogen granule glycoprotein 2 antibodies; ASCA, anti-Saccharomyces cerevisiae antibody; Anti-TNF, therapy with anti-TNF; Duration, disease duration; L,location of disease (L1, ileal); age, age at diagnosis;
Significant relationships between one dichotomous dependent variable (various clinical outcomes or treatment variants) and one or more independent variables including aGP2 and ASCA, gender, age, disease duration, surgery are shown (P<0.003 respectively). (only significant correlations are shown).