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. 2018 Feb 28;8:3824. doi: 10.1038/s41598-018-22174-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Representative calcium profile of individual MSCs responding to OFS generating 1 Pa, 1 Hz. OFS begins at t = 0 s. Cells treated with vehicle alone, DMSO, represented in the solid green; those treated for 1 hour pre mechanical stimulation with 10 µM GSK205 are in the purple dashed line. Baseline values calculated from the 20 seconds prior to the application of OFS. The dashed black line at 1.2-fold change marks the value above which cells are considered to be responsive. (B) Median ± Interquartile range fold increase in calcium at first peak following application of treatment. Vehicle: N = 4, n = 9; GSK205: N = 4, n = 22, Mann Whitney test, ***p < 0.001. (C) Frequency of cells responding to the stimulus. Median ± Interquartile: Vehicle: N = 4, n = 22; GSK205: N = 4, n = 11, Fisher’s exact test, *p < 0.05. (D) Time to first peak for individual cells following application of stimulus at time 0 s. Bars mark Median ± Interquartile, Vehicle: N = 4, n = 9; GSK205: N = 4, n = 22 ND = None determined, no responsive cells observed.