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. 2017 Nov 23;118(4):566–576. doi: 10.1038/bjc.2017.414

Figure 3.

Figure 3

Activated HSCs and primary liver NPCs secrete high level of IL-8 and MCP-1. (A) Representative images of protein array analysis on cells cultured in HMM and (B) average density of selected cytokines corrected to reference positive controls and normalised to cell number with SD (n=2). (C) Representative images of secretome analysis of LX-2 cells cultured on 0.3 kPa and 40 kPa PA gels in DMEM+0.2% dialyzed FBS and average spot density of selected cytokines normalised to cell number with SD (n=4). (D) Average mean fluorescence intensity (MFI) of chemokines/cytokines with standard error of the mean measured using Luminex assay on supernatants from primary human hepatocytes±NPC cultured in 3D Liver MPS in serum-free William’s E medium (n=2 donors). *P<0.05.