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. 2017 Dec 12;118(4):495–508. doi: 10.1038/bjc.2017.433

Figure 6.

Figure 6

The effect of 24 h treatment with combinations of MDM2 and WIP1 inhibitors on cell cycle distribution and apoptosis. Melanoma cells were treated by either 2.5 μM WIP1i, 0.2 μM RG7388, 0.2 μM HDM201 or combinations for 24 h. (A) Cell cycle distribution changes by FACS analysis. (B) Sub-G1 events by FACS and (C) caspase-3/7 activity were used as indicators of apoptosis. Statistically significant P-values (*P<0.05) are indicated. Data are presented as mean±s.e.m. for three independent repeats.