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. 2018 Feb 28;8:3764. doi: 10.1038/s41598-018-19700-8

Table 2.

Hazard ratios and 95% confidence intervals for myocardial infarction, ischemic stroke, and death according to quartiles of liver enzymes.

Myocardial infarction Ischemic stroke Death
Event Duration IR HR (95% Cl) Event Duration IR HR (95% Cl) Event Duration IR HR (95% Cl)
ALT Q1 48700 36870026 1.32 1.00 (ref.) 59161 36847085 1.61 1.00 (ref.) 179742 37046039 4.85 1.00 (ref.)
Q2 54532 35893859 1.52 1.00 (0.99, 1.01) 65599 35869654 1.83 1.00 (0.99, 1.01) 154118 36102372 4.27 0.89 (0.89, 0.90)
Q3 58359 34273199 1.70 1.02 (1.01, 1.03) 68356 34255343 2.00 1.02 (1.01, 1.03) 147344 34501798 4.27 0.91 (0.91, 0.92)
Q4 69993 37444966 1.87 1.10 (1.07, 1.10) 77226 37438130 2.06 1.06 (1.05, 1.07) 177221 37720098 4.70 1.17 (1.17, 1.18)
AST Q1 40948 34854743 1.17 1.00 (ref.) 45806 34849351 1.31 1.00 (ref.) 110512 35011148 3.16 1.00 (ref.)
Q2 55205 38434636 1.44 0.97 (0.96, 0.98) 61766 38427855 1.61 0.95 (0.94, 0.96) 143560 38648886 3.71 0.91 (0.90, 0.92)
Q3 62827 37579639 1.67 0.97 (0.96, 0.98) 74750 37556028 1.99 0.96 (0.95, 0.97) 166036 37823728 4.39 0.95 (0.94, 0.95)
Q4 72604 33613032 2.16 1.05 (1.04, 1.06) 88020 33576979 2.62 1.04 (1.03, 1.05) 238317 33886545 7.03 1.30 (1.30, 1.31)
GGT Q1 42421 36982585 1.15 1.00 (ref.) 48844 36974336 1.32 1.00 (ref.) 138441 37142806 3.73 1.00 (ref.)
Q2 51835 36735422 1.41 1.08 (1.06, 1.09) 59570 36723544 1.62 1.09 (1.08, 1.11) 143240 36934518 3.88 1.05 (1.04, 1.06)
Q3 60810 35233338 1.73 1.16 (1.15, 1.17) 70169 35217336 1.99 1.20 (1.18, 1.21) 153119 35470795 4.32 1.15 (1.14, 1.16)
Q4 76518 35530706 2.15 1.27 (1.26, 1.29) 91759 35494998 2.59 1.36 (1.34, 1.37) 223625 35822188 6.24 1.64 (1.63, 1.66)

IR, incidence rate per 1000.

Hazard ratio was analyzed after adjusting for age, sex, body mass index, smoking, alcohol, exercise, diabetes, hypertension, and dyslipidemia.