Table 3.
Hazard ratios and 95% confidence intervals for mortality according to quartiles of liver enzymes after myocardial infarction or ischemic stroke.
| Event | Duration | MR | Model 1 | Model 2 | ||
|---|---|---|---|---|---|---|
| HR (95% Cl) | HR (95% Cl) | |||||
| ALT | Q1 | 6218 | 21507006 | 0.29 | 1.00 (Ref) | 1.00 (Ref) |
| Q2 | 3841 | 20805510 | 0.18 | 0.73 (0.70, 0.76) | 0.80 (0.76, 0.83) | |
| Q3 | 3571 | 22471487 | 0.16 | 0.70 (0.67, 0.73) | 0.80 (0.77, 0.84) | |
| Q4 | 3252 | 21550048 | 0.15 | 0.78 (0.74, 0.81) | 0.93 (0.89, 0.97) | |
| AST | Q1 | 5024 | 23428822 | 0.21 | 1.00 (Ref) | 1.00 (Ref) |
| Q2 | 3378 | 18599784 | 0.18 | 0.83 (0.80, 0.87) | 0.87 (0.83, 0.91) | |
| Q3 | 3929 | 22604257 | 0.17 | 0.80 (0.77, 0.83) | 0.85 (0.82, 0.89) | |
| Q4 | 4551 | 21702283 | 0.21 | 1.02 (0.98, 1.06) | 1.09 (1.04, 1.13) | |
| GGT | Q1 | 4622 | 20642384 | 0.22 | 1.00 (Ref) | 1.00 (Ref) |
| Q2 | 4061 | 21699165 | 0.19 | 0.93 (0.89, 0.97) | 1.03 (0.99, 1.07) | |
| Q3 | 3740 | 22372024 | 0.17 | 0.92 (0.88, 0.96) | 1.08 (1.04, 1.13) | |
| Q4 | 4459 | 21619018 | 0.21 | 1.24 (1.19, 1.29) | 1.46 (1.40, 1.52) |
MR, mortality rate (per 1000 person-years); HR, hazard ratio; CI, confidence interval; ALT, alanine aminotransferase; AST, aspartate aminotransferase; GGT, γ-glutamyltransferase.
Model 1: HRs were analyzed after adjusting for age and sex.
Model 2: HRs were analyzed after adjusting for age, sex, body mass index, smoking, alcohol, exercise, diabetes, hypertension, and dyslipidemia.