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. 2018 Feb 6;12(3):373–390. doi: 10.1002/1878-0261.12171

Figure 5.

Figure 5

AP4 promotes HCC cell growth via LAPTM4B by affecting cell cycle in vitro and in vivo. (A, B) Restoration of LAPTM4B significantly reversed the cycle arrest at the G1 phase induced by AP4 knockdown in Huh7 cells (n = 3, mean ± SD) (**P < 0.01). (C) The expression of cell cycle‐related proteins p21 and p27 was upregulated, and the expression of cyclin E was downregulated in Huh7 cells with stable AP4 knockdown, while restoration of LAPTM4B significantly reversed these expression levels.