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Effects of six different MOR ligands in an assay of thermal nociception in male rhesus monkeys. Top panel shows effects of NAQ, nalbuphine, buprenorphine, morphine oxycodone, and methadone at 50°C; bottom panel shows effects at 54°C. Abscissae: cumulative intramuscular drug dose (milligrams per kilogram). Ordinates: %MPE. All points represent mean ± S.E.M. value of four monkeys.
