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Effects of cumulative fentanyl (0.001–0.32 mg/kg, i.m.) administered either alone or following a 15-minute pretreatment with either 10 mg/kg NAQ (left panels) or 0.032 mg/kg fentanyl/naltrexone (1:0.22) (right panels) in rhesus monkeys. Abscissae: cumulative intramuscular fentanyl dose (milligrams per kilogram). Ordinates: %MPE. All points represent the mean ± S.E.M. value of four monkeys. Solid points denote statistical significance (P < 0.05) compared with fentanyl alone.
