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. 2018 Apr;365(1):37–47. doi: 10.1124/jpet.117.246439

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Fig. 6. — Time course of antinociceptive effects of 0.056 mg/kg fentanyl in combination with 0.0041 mg/kg naltrexone administered simultaneously as a bolus dose of the 1:0.074 fentanyl/naltrexone mixture or with the naltrexone dose administered as a 3-minute pretreatment to the fentanyl dose in rhesus monkeys. Antinociceptive effects of cumulative 0.056 mg/kg 1:0.074 fentanyl/naltrexone from Fig. 2 are also plotted for comparison. Abscissae: fentanyl dose (milligrams per kilogram). Ordinate: %MPE. Each point represents the mean ± S.E.M. value of four monkeys.