TABLE 1.
Group mean %MPEmax values and (±S.E.M.) for each fentanyl/naltrexone combination or test drug administered in an assay of thermal nociception at 50 and 54°C in rhesus monkeys (n = 4)
| Drug or Drug Mixture | %MPEmax (S.E.M.) |
|
|---|---|---|
| 50°C | 54°C | |
| Fentanyl | 100 (0)a,b | 96.4 (2.8)a,b |
| 1:0.025 Fentanyl/naltrexone | 100 (0)a,b | 95.3 (4.7)a,b |
| 1:0.074 Fentanyl/naltrexone | 70.8 (24.2) | 40.4 (14.9) |
| 1:0.22 Fentanyl/naltrexone | 14.5 (9.5) | 12.9 (10.7) |
| (−)-Naltrexone | −1.8 (5.6) | 0.9 (0.4) |
| (±)-Methadone | 100 (0) | 100 (0) |
| (−)-Oxycodone | 100 (0) | 89.5 (6.7) |
| (−)-Morphine | 100 (0) | 78.1 (9.9) |
| (−)-Nalbuphine | 100 (0) | 64.1 (14.5) |
| (±)-Buprenorphine | 93.3 (6.7) | 14.0 (6.0) |
| NAQ | 8.9 (6.9) | 5.1 (3.7) |
a
Significantly different from naltrexone (P < 0.05).
b
Significantly different from the 1:0.22 fentanyl/naltrexone mixture (P < 0.05).