TABLE 2.

Individual %MPE_max values for each fentanyl/naltrexone combination or test drug administered in an assay of thermal nociception at 50 and 54°C in rhesus monkeys

Drug or Drug Mixture	%MPEmax
	50°C				54°C
	M1414	M1473	M1478	M1503	M1414	M1473	M1478	M1503
Fentanyl	100	100	100	100	87	100	100	100
1:0.025 Fentanyl/naltrexone	100	100	100	100	81.1	100	100	100
1:0.074 Fentanyl/naltrexone	84.2	100	100	3.3	37.6	62.7	62.2	4.7
1:0.22 Fentanyl/naltrexone	9	6.6	42.2	10.4	18.1	10	44.2	1.1
(−)-Naltrexone	9.5	2.1	−12.6	−1.6	3.2	1.8	−0.3	0.6
(±)-Methadone	100	100	100	100	100	100	100	100
(−)-Oxycodone	100	100	100	100	71.4	100	86.1	100
(−)-Morphine	100	100	100	100	74.9	52.8	84.7	100
(−)-Nalbuphine	100	100	100	100	52.8	100	71.9	31.7
(±)-Buprenorphine	73.2	100	100	100	32.1	18.7	29.3	16.5
NAQ	4.6	5.9	28.8	8	6.4	1.1	16.1	2.8