Fig. 3.
Synergistic effects of D1 plus D2 dopamine receptor activation on the severity of cerebellar mediated dystonia. Administration of a low dose of quinpirole (0.5 mg/kg) did not affect the severity of dystonia compared with vehicle administration (two-tailed Student’s t test, t = 0.629). However, administration of quinpirole plus SKF-81297 significantly reduced the severity of dystonia induced by cerebellar microinjection of kainate (one-way ANOVA; F3,30 = 4.841, P < 0.01, n = 7–11/dose). Disability scores lower than 10 (dashed lines) suggest abnormal motor behavior, such as an unsteady gait, but not overt dystonia. Values represent the mean of the cumulative disability score in 1 hour ± S.E.M.; *P < 0.05 compared with quinpirole alone, Holm-Sidak multiple comparisons test.