Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Feb 7;5(2):171058. doi: 10.1098/rsos.171058

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2018 The Authors.

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

PMC Copyright notice

Figure 5. — The HIF-1 signalling pathway is enriched in proteins containing labile disulfide bonds. The proteins containing labile disulfide bonds are shown in orange. Grey indicates that no X-ray structures are available of this protein. RTK: epidermal growth factor receptor/erb-b2 receptor tyrosine kinase. MEK: mitogen-activated protein kinase ½. ERK: mitogen-activated protein kinase 1/3. MNK: MAP kinase interacting kinase ½. STAT3: signal transducer and activator of transcription 3. 4E-BP1: eukaryotic translation initiation factor 4E-binding protein. eIf4E: eukaryotic translation initiation factor 4E. p70S6 K: ribosomal protein S6 kinase. Rps6: ribosomal protein S6. VHL: Von Hipper Lindau tumor suppressor. RBX1: ring box 1. CUL2: cullin 2. PI3 k: phosphoinositide-3-kinase. AKT: protein kinase B. mTOR: mechanistic target of rapamycin. ElonginC: transcription elongation factor B subunit 1. ElonginB: transcription elongation factor B subunit 2. PHD2: Egl-9 family hypoxia inducible factor 1. CamK: calcium/calmodium-dependent protein kinase. ep300: E1A-binding protein p300. PLCɣ: phospholipase C gamma. NOX: NADPH oxidase. Glut: solute carrier family 2 member 1. TIMP-1: TIMP metallopeptidase inhibitor 1. CD18: lymphotoxin beta receptor. EPO: erythropoietin. TF: transferrin. TFRC: transferrin receptor. VEGF: vascular endothelial growth factor. Flt-1: Fms-related tyrosine kinase 1. EGF: epidermal growth factor. TEK tyrosine Kinase: TIE-2, angiopoietin-1 receptor. EDN1: endothelin 1. NOS2/3: nitric oxide synthase 2/3. ANP: natriuretic peptide A. PDK-1: pyruvate dehydrogenase kinase 1. HK: hexokinase. PFKL: ATP-dependent 6-phosphofructokinase. GAPDH: glyceraldehyde-3-phosphate dehydrogenase. ALDOA: fructose-bisphosphate aldolase A. ENO1: enolase 1. PGK1: phosphoglycerate kinase 1. PFK2: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3. LDHA: l-lactate dehydrogenase A chain. Bcl-2: apoptosis regulator Bcl-2. p21/p27: cyclin-dependent kinase inhibitor 1.