Table 1.
Labile disulfide bonds in coagulation proteins. The first four characters are the PDB identifier followed by the strand. Underlined are the PDB structures used in figure 4.
| protein | disulfide Cys | PDB with bond | PDB missing bond | configuration |
|---|---|---|---|---|
| coagulation factor X | 168–182 | KQCAa | 3CENA, 2P95A | +/–RHspiral |
| urokinase plasminogen activator | 11–19 | 3BT2A, 2I9AA, 2I9AC, 2I9AD | 2FD6A | –/+LHhook |
| 50–111 | 2R2WUb | 4X1NU, 4H42U, 4ZHLU, 4ZKSU, 1OWEA, 1OWHA | –RHstaple | |
| 136–201 | 2R2WUc | 4ZHLU | –RHstaple | |
| plasminogen | 481–560 | 5HPGA, 5HPGB, 4DURA | 4DURB | –/+RHhook |
a2W3KA3, 2VH6A, 3M37A, 2XBVA, 3KL6A, 3K9XB, 3K9XD, 2WYGA, 2Y80A, 4Y7AA, 2J34A, 3HPTB, 3HPTD, 2CJIA, 1NFYA, 2UWPA, 5K0HA, 3TK6A, 2Y81A, 2H9EH, 2RA0A, 1NFWA, 2EI7A, 2Y82A, 2Y5FA, 3M36A, 1MQ5A, 4Y7BA, 1F0SA, 2PHBA, 4BTUB, 4BTUF, 2P94A, 3LIWA, 2Y5HA, 2Y5GA, 2XC0A, 1XKAC, 1FJSA, 3CS7A, 2Y7XA, 2UWOA, 2UWOA, 3FFGA, 2FZZA, 2J4IA, 2J95A, 1WU1A, 4Y76A, 2D1JA, 2VWOA, 2VWNA, 1LPKB, 3Q3KA, 2VWLA, 2VWMA, 2VWMB, 4Y71A, 2P3UB, 2PR3A, 2P93A, 2W3IA, 2P16A, 3TK5A, 4ZHAA, 4BTIB, 4BTIF, 2Q1JA, 3KQEA, 2EI6A, 2Y7ZA, 3SW2B, 2G00A, 2P3TB, 1LPGB, 1LPZB, 3KQBA, 1NFUA, 3ENSB, 3ENSD, 1NFXA, 2VVVA, 1G2LA, 4A7IB, 2BOHB, 2JKHA, 1EZQA, 2J94A, 2BOKA, 2UWLA, 3IITA, 1KSNA, 1F0RA, 2XBWA, 2WYJA, 2VVCA, 2VVCB, 2VVUA, 2XC4A, 2J2UA, 1V3XA, 1Z6EA, 2XBYA, 1HCGA, 2XBXA, 4Y6DA, 2BQ7B, 2J38A, 2XC5A, 4Y79A, 2VH0A, 4ZH8A, 1XKBC, 1XKBD, 1MQ6A, 1C5MD, 2W26A, 2EI8A.
b4FU9A, 3OY5U, 3IG6B, 1W11U, 3KGPA, 2O8UA, 1W10U, 1W0ZU, 3OX7U, 3M61U, 4JNIU, 4OS1A, 1SQAA, 4FUEA, 1GJ7B, 2VIQA, 1U6QA, 1GJAB, 4FUGA, 1C5ZB, 3MWIU, 4OS6A, 1W12U, 4FUIA, 2VIVA, 4FUCA, 1EJNA, 4FU8A, 1VJAU, 1GJ9B, 4JK5A, 2VIPA, 3OY6U, 1SQOA, 4MNXA, 1GJDB, 1F5LA, 1SC8U, 1SQTA, 2VIWA, 4X0WU, 1W14U, 4OS2A, 4FUBA, 2O8WA, 1GI7B, 1O5BB, 1GJ8B, 4FU7A, 4OS4A, 4MNVA, 3MHWU, 3PB1E, 4ZKNU, 1LMWB, 1LMWD, 4MNYA, 4MNYB, 4X1RU, 1W13U, 4X1QU, 1VJ9U, 4ZHMU, 1GJBB, 3KHVA, 2VIOA, 1GJCB, 4FUHA, 2NWNA, 1GI8B, 1OWDA, 4JNLU, 4ZKRU, 2VNTA, 2VNTB, 2VNTC, 2VNTD, 2VNTE, 2VNTF, 2VINA, 1O5AB, 1GI9B, 4ZKOU, 1C5WB, 4X1SU, 4FUFA, 2O8TA, 4OS5A, 1C5XB, 1O5CB, 4X1PU, 4JK6A, 4OS7A, 3QN7A, 1O3PB, 4XSKU, 4FUJA, 1F5KU, 5HGGA, 5HGGB, 4FUDA, 4DVAU, 4MNWA, 4GLYA, 1C5YB.
c4FU9A, 3OY5U, 3IG6B, 1W11U, 4X1NU, 3KGPA, 4H42U, 2O8UA, 1W10U, 1W0ZU, 3OX7U, 3M61U, 4JNIU, 4OS1A, 1SQAA, 4FUEA, 1GJ7B, 2VIQA, 1U6QA, 1GJAB, 4FUGA, 1C5ZB, 3MWIU, 4OS6A, 1W12U, 4FUIA, 2VIVA, 4FUCA, 1EJNA, 4FU8A, 1VJAU, 1GJ9B, 4JK5A, 2VIPA, 3OY6U, 1SQOA, 4MNXA, 1GJDB, 1F5LA, 1SC8U, 1SQTA, 2VIWA, 4X0WU, 1W14U, 4ZKSU, 4OS2A, 4FUBA, 2O8WA, 1GI7B, 1O5BB, 1GJ8B, 4FU7A, 4OS4A, 4MNVA, 3MHWU, 3PB1E, 4ZKNU, 1LMWB, 1LMWD, 4MNYA, 4MNYB, 4X1RU, 1W13U, 4X1QU, 1VJ9U, 4ZHMU, 1GJBB, 3KHVA, 2VIOA, 1GJCB, 1OWEA, 4FUHA, 2NWNA, 1GI8B, 1OWDA, 4JNLU, 4ZKRU, 2VNTA, 2VNTB, 2VNTC, 2VNTD, 2VNTE, 2VNTF, 2VINA, 1O5AB, 1GI9B, 4ZKOU, 1C5WB, 4X1SU, 4FUFA, 2O8TA, 4OS5A, 1C5XB, 1O5CB, 4X1PU, 4JK6A, 4OS7A, 3QN7A, 1O3PB, 4XSKU, 4FUJA, 1F5KU, 5HGGA, 5HGGB, 4FUDA, 4DVAU, 4MNWA, 1OWHA, 4GLYA, 1C5YB.