Table 2.
Labile disulfide bonds in the HIF-1 signalling pathway. The first four characters are the PDB identifier followed by the strand. Underlined are the PDB structures used in figure 6.
| protein | disulfide Cys | PDB with bond | PDB missing bond | configuration |
|---|---|---|---|---|
| AKT1 | 60–77 | 4EJNA, 2UZRA, 1UNPA, 1UNRA | 1UNQA, 1H10A, 2UZSA, 2UVMA | –RHstaple |
| EP300 | 1796–1801 | 3P57P | 3IO2A | +/–RHspiral |
| 1796–1806 | 3P57P | 3IO2A | +LHspiral | |
| Egl 9 homolog 1 (PHD2) | 201–208 | 4BQYA, 3OUIA, 4BQXA, 4JZRA, 5LATA, 4BQWA, 2Y33A, 3HQRA, 5LBEA, 5LBFA, 2HBTA, 5LBBA, 5LB6A | 4UWDA, 3HQUA, 4KBZA, 3OUJA, 2HBUA, 5LBCA, 2G19A, 2G1MA, 2Y34A | +/–LHspiral |
| EGFR | 510–523 | 1MOXA, 1MOXB, 3P0YA, 4UV7A, 5SX5N | 5SX5M | –RHstaple |
| PIK3CG | 357–524 | 4FULA | 4ANVA,3R7QA,5G55A | –LHstaple |