Figure 2.

Telmisartan and esculetin combination prevented hyperresponsiveness to Ang II and restored endothelial-dependent relaxation. (a) Ang II and (b) acetylcholine-mediated cumulative concentration response curve (CRC) in aortic ring obtained from normal control; normal control rats, type 2 diabetic control; type 2 diabetic control, T2DC+E; type 2 diabetic control treated with esculetin, T2DC+T; type 2 diabetic control treated with telmisartan, T2DC+C; type 2 diabetic control treated with combination of esculetin and telmisartan. Note: Each data is represented as means ± standard error of mean (n = 6). *P < 0.05 versus NC;^#P < 0.05 versus T2DC;^$P < 0.05 versus T2DC+E;^@P < 0.05 versus T2DC+T