Figure 1.

Mutational characteristics. Mutational details of exome sequencing of primary and metastatic samples of Patient 1–5. (A) Mutational categories according to mutations found only in the metastasis sample, only in the primary sample or in both samples (common). (B) Distribution of transversions and transitions according to presence in primary, metastasis or both (common). (C) Distribution of allele frequencies (AF) of mutations detected only in the primary lesion, only in the metastasis, or in both samples (common). Observed allele frequencies were scaled to account for estimated tumor content (given in brackets).