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. 2018 Feb 28;8:3770. doi: 10.1038/s41598-018-22090-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The identified active molecule, 5-OH-S, inhibits AMPK kinase activity. (A) Structure of 5-OH-S. (B) Dose-dependent inhibition of recombinant AMPKα1β1γ1 and recombinant AMPKα2β1γ1 kinase activity by 5-OH-S. (C) Lineweaver-Burke plots of AMPK substrate phosphorylation in the presence of DMSO or 500 nM 5-OH-S. (D) Immunoblots of total and phosphorylated ACC (Ser79), RAPTOR (Ser792) and AMPK (Thr172) after 48-hour treatment with 7.5 μM 5-OH-S in HCT116 and SW480 cells.