Table 1.
Classical Type I cadherins. Nomenclature, genomic position, and cancer role
| Trivial name | Gene symbol* | Gene location* | Role in cancer | References |
|---|---|---|---|---|
| E-cadherin | CDH1 (Cdh1) | 16q22.1 (8:10.66Mb) | Tumor suppressor | Berx et al. 1995; Guilford et al. 1998; Perl et al. 1998; Derksen et al. 2006 |
| N-Cadherin | CDH2 (Cdh2) | 18q12.1 (18:16.58Mb) | Oncogene | Islam et al. 1996; Hazan et al. 1997a |
| P-cadherin | CDH3 (Cdh3) | 16q22.1 (8:10.65Mb) | Multiple | Radice et al. 1997; Peralta Soler et al. 1999; Paredes et al. 2004 |
| R-cadherin | CDH4 (Cdh4) | 20q13.33 (2:17.94Mb) | Tumor suppressor | Agiostratidou et al. 2009 |
| M-cadherin | CDH15 (Cdh15) | 16q24.3 (8:122.84Mb) | Tumor suppressor | Cool and Jolicouer 1999; Yamada et al. 2007 |
*Information in parentheses depicts nomenclature (Gene symbol) or chromosomal positioning (Gene location) for Mus musculus. Mb=Megabase.