Figure 1.

Schematic Diagram of Mouse Postimplantation Germ Cell Development in Symmetric Self-Renewal Proliferation and Migration

(A) Germ cell development profile under different oxygen tension conditions during embryogenesis.

(B) Germ cell developmental profile. (a and b) AP staining (in red). (a) i–iv: symmetric self-renewal division (Sym.) of AP⁺GSCs. v: partial migratory AP⁺GSCs under embryonic hypoxia. (b) i–iv: asymmetric division (Asym.) of AP⁺GSCs. AP, alkaline phosphatase; ExE, extraembryonic ectoderm; EPI, epiblast; PS, primitive streak; VE, visceral endoderm; AP⁺PGCs, PGCs with AP activity (in red); A_s, undifferentiated A single spermatogonia; A₁, differentiating A₁ spermatogonia; PL, preleptotene spermatocytes; E, embryonic day; P, postnatal day. Scale bars, 25 μm. See also Figure S3.