Figure 7.

Proposed Model of HP1γ Interactions

In non-pluripotent cells and reprogramming intermediates, HP1γ interacts with SENP7, which anchors HP1γ to H3K9me2/3 histones in the heterochromatin, depicted as red or yellow circles. HP1γ is also more enriched with linker histone H1 in reprogramming intermediates. During reprogramming, the release of HP1γ from being anchored to the heterochromatin is required to attain pluripotency. In pluripotent cells, HP1γ interacts with histone H3.3 and histone elongation mark H3K79me2. Moreover, OCT4 and DPPA4 are among the interactors of HP1γ in pluripotent cells that occur independently of H3K9me3 but may be dependent on other modifications (black circle).