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. 2017 Oct 19;9(5):1369–1376. doi: 10.1016/j.stemcr.2017.09.016

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© 2017 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Osteoclasts Differentiated from Healthy Control and CMD hiPSCs

(A) Comparison of control and CMD osteoclasts derived from hiPSCs. Numbers of TRAP+ multinucleated cells (nuclei ≥3) are shown (mean ± SD) in the left corners of the images. Different letters (a, b) indicate statistically significant difference (p < 0.05) by one-way ANOVA. Scale bar, 100 μm.

(B) Decreased sizes of osteoclasts derived from CMD1 and CMD2 hiPSCs. Yellow bars indicate the mean value of each group (n ≥ 400 osteoclasts measured per group). Different letters (a, b, c) indicate statistically significant difference (p < 0.05) by one-way ANOVA.

(C) Decreased expression of TRAP, CATHEPSIN K, CALCITONIN RECEPTOR mRNA message in osteoclasts differentiated from CMD hiPSCs shown by qPCR. ^∗p < 0.05 by two-way ANOVA. Data presented are means ± SD. Three independent experiments (technical replicates) were performed for each hiPSC line.