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. 2017 Nov 1;9(5):1395–1405. doi: 10.1016/j.stemcr.2017.09.020

Figure 2.

Figure 2

Enrichment of Bi-DOCS and Fi-DOCS in Chromatin States

(A) Enrichment (x axis) of DOCS in Epigenome Roadmap chromatin states (y axis) grouped according to pluripotent cell/germ layer type. Bold red states were enriched across all germ layer and pluripotent stem cell states while # indicates that ESC/iPSC states had highest enrichment.

(B) Log2FE ratio (x axis) of Bi-DOCS versus Fi-DOCS across chromatin states (y axis) enriched in (A). Bold red states are enriched for Bi-DOCS while # shows states most enriched for Fi-DOCS in ESC/iPSC lines.

(C) Log2FE ratio (x axis) of Bi-DOCS versus Fi-DOCS across chromatin states and FOXA2 TFBS (shape/color) identified during different stages (y axis) of endodermal development. human stem cells (hESC, FOXA2 not available), definitive endoderm (DE), gut tube (GT), fore gut (FG), and pancreatic endoderm (PE).

(D) Log2FE ratio (x axis) of Bi-DOCS versus Fi-DOCS across HESC-H1 (stem cell, red), HeLaS3 (ectoderm, dark yellow), K562 (mesoderm, green), HepG2 (endoderm, blue), and islet (endoderm, purple) TFBS (y axis).