Table 1.
Bi-DOCS-Associated GO Biological Processes and MSigDB Pathways Terms
| Term | Pathway Description | DOCS Trend | Gene Number | Region Enrichment | Gene Enrichment | Regional FDR | Gene FDR | Associated Function |
|---|---|---|---|---|---|---|---|---|
| GO | neural tube patterning | Bi-DOCS | 80 | 3.27 | 2.69 | 8.7 × 10−17 | 2.4 × 10−5 | neuro-developmental |
| GO | positive regulation of embryonic development | Bi-DOCS | 51 | 4.75 | 3.23 | 1.0 × 10−16 | 9.3 × 10−3 | developmental |
| GO | non-canonical Wnt receptor signaling pathway | Bi-DOCS | 65 | 3.55 | 2.10 | 2.4 × 10−15 | 3.9 × 10−2 | WNT/NOTCH signaling |
| GO | hindbrain morphogenesis | Bi-DOCS | 82 | 2.84 | 2.32 | 4.1 × 10−14 | 4.1 × 10−4 | neuro-developmental |
| GO | branching involved in mammary gland duct morphogenesis | Bi-DOCS | 68 | 3.20 | 2.53 | 5.2 × 10−14 | 3.0 × 10−3 | developmental |
| GO | cerebellum morphogenesis | Bi-DOCS | 75 | 2.86 | 2.36 | 4.9 × 10−13 | 6.8 × 10−4 | neuro-developmental |
| GO | mammary gland duct morphogenesis | Bi-DOCS | 94 | 2.39 | 2.47 | 6.2 × 10−12 | 1.8 × 10−4 | developmental |
| GO | mammary gland epithelium development | Bi-DOCS | 123 | 2.10 | 2.12 | 9.1 × 10−12 | 1.4 × 10−4 | developmental |
| GO | dorsal spinal cord development | Bi-DOCS | 51 | 3.42 | 2.57 | 1.4 × 10−11 | 3.8 × 10−3 | neuro-developmental |
| GO | cerebellum development | Bi-DOCS | 110 | 2.10 | 2.02 | 1.4E-10 | 1.1 × 10−4 | neuro-developmental |
| GO | cerebellar cortex morphogenesis | Bi-DOCS | 58 | 2.91 | 2.31 | 1.9E-10 | 6.6 × 10−3 | neuro-developmental |
| GO | spinal cord association neuron differentiation | Bi-DOCS | 38 | 3.83 | 2.69 | 5.6E-10 | 1.6 × 10−2 | neuro-developmental |
| GO | dorsal/ventral neural tube patterning | Bi-DOCS | 50 | 2.99 | 2.83 | 2.0 × 10−9 | 9.5 × 10−4 | neuro-developmental |
| GO | negative regulation of Notch signaling pathway | Bi-DOCS | 34 | 3.73 | 2.55 | 1.1 × 10−8 | 1.0 × 10−2 | WNT/NOTCH signaling |
| GO | cell differentiation in spinal cord | Bi-DOCS | 93 | 2.07 | 2.83 | 1.1 × 10−8 | 2.6 × 10−9 | neuro-developmental |
| GO | cell differentiation in hindbrain | Bi-DOCS | 55 | 2.61 | 2.64 | 2.4 × 10−8 | 1.6 × 10−3 | neuro-developmental |
| GO | cerebellar cortex development | Bi-DOCS | 65 | 2.38 | 2.02 | 2.8 × 10−8 | 8.8 × 10−3 | neuro-developmental |
| GO | somitogenesis | Bi-DOCS | 93 | 2.00 | 2.05 | 4.6 × 10−8 | 4.1 × 10−4 | developmental |
| GO | white fat cell differentiation | Bi-DOCS | 29 | 3.37 | 2.69 | 1.3 × 10−6 | 4.5 × 10−2 | developmental |
| GO | embryonic axis specification | Bi-DOCS | 65 | 2.10 | 2.02 | 2.0 × 10−6 | 1.9 × 10−2 | developmental |
| GO | ventral spinal cord interneuron fate commitment | Bi-DOCS | 34 | 2.91 | 3.67 | 2.8 × 10−6 | 3.1 × 10−4 | neuro-developmental |
| GO | regulation of insulin receptor signaling pathway | Bi-DOCS | 44 | 2.44 | 2.02 | 5.0 × 10−6 | 3.3 × 10−2 | diabetes/insulin |
| GO | positive regulation of focal adhesion assembly | Bi-DOCS | 25 | 3.46 | 2.80 | 5.7 × 10−6 | 1.9 × 10−2 | other |
| GO | cerebellar cortex formation | Bi-DOCS | 40 | 2.54 | 2.43 | 6.4 × 10−6 | 1.8 × 10−2 | neuro-developmental |
| GO | regulation of Notch signaling pathway | Bi-DOCS | 58 | 2.06 | 2.21 | 1.4 × 10−5 | 1.1 × 10−3 | WNT/NOTCH signaling |
| GO | spinal cord dorsal/ventral patterning | Bi-DOCS | 39 | 2.34 | 2.55 | 4.3 × 10−5 | 1.0 × 10−2 | neuro-developmental |
| GO | ventral spinal cord interneuron differentiation | Bi-DOCS | 35 | 2.46 | 3.42 | 5.0 × 10−5 | 4.1 × 10−4 | neuro-developmental |
| MSigDB pathway | Wnt signaling network | Bi-DOCS | 53 | 2.68 | 2.31 | 9.4 × 10−8 | 2.8 × 10−2 | WNT/NOTCH signaling |
| MSigDB pathway | maturity-onset diabetes of the young | Bi-DOCS | 40 | 2.15 | 2.43 | 3.0 × 10−4 | 2.5 × 10−2 | diabetes/insulin |