Table 2.
SUMMARIZED BRUNT SCORE OF NOTABLE HISTOLOGIC FEATURESa
| Offspring Diet: | CH | WD | WDPQQ | WDPQQ/WD | P Value |
|---|---|---|---|---|---|
| Steatosis | 0.17 ± 0.18§ | 2.17 ± 0.18 | 1.00 ± 0.28‡ | 1.50 ± 0.24† | <0.0001 |
| Fibrosis | 1.00 ± 0.21§ | 2.58 ± 0.25 | 0.96 ± 0.19§ | 0.82 ± 0.19§ | <0.0001 |
| Inflammation | 0.00 ± 0.00§ | 5.33 ± 0.37 | 1.83 ± 0.91‡ | 2.33 ± 0.83‡ | 0.0001 |
| Liver cell Injury | 0.00 ± 0.00‡ | 1.67 ± 0.37 | 0.00 ± 0.00‡ | 0.33 ± 0.37† | 0.0005 |
| Reactive change | 0.00 ± 0.00‡ | 1.67 ± 0.37 | 0.00 ± 0.00‡ | 0.67 ± 0.46 | 0.0019 |
| Total | 1.17 ± 0.28§ | 13.41 ± 0.71 | 3.80 ± 0.97§ | 5.65 ± 1.07§ | <0.0001 |
a
One‐way analysis of variance performed with the Tukey correction for multiple comparisons between groups. P values demonstrating significant differences between groups are shown in bold. Data are mean ± SEM, n = 6/group. Fibrosis scores were obtained from quantitation of positive pixels per 100 × field in picrosirius red‐stained sections viewed under cross‐polarized light (Fig. 2A). Scores were averaged per group and normalized to the CH‐fed mice. Total represents the sum of mean scores for all histologic features. Mann‐Whitney U tests used for pairwise comparisons to WD/WD: † P < 0.05, ‡ P < 0.01, § P < 0.001.