Table 1. Metabolic genesets enriched when genes are ranked by the correlation coefficient for change in gene expression and change in clinical parameter.
Clinical Parameter | Time clinical parameter assessed (h) | Geneset | Time gene expression assessed (h) | ES | NES | p | padj |
---|---|---|---|---|---|---|---|
LPS | 2 | Heme metabolism | 2 | 0.42 | 1.24 | 0.01 | 0.72 |
LPS | 2 | Heme metabolism | 6 | 0.41 | 1.28 | 0.03 | 1.00 |
LPS | 6 | Heme metabolism | 2 | 0.42 | 1.39 | 0.00 | 0.04* |
LPS | 6 | Heme metabolism | 4 | 0.49 | 1.61 | 0.00 | 0.001* |
LPS | 6 | Heme metabolism | 6 | 0.38 | 1.22 | 0.04 | 1.00 |
Total cholesterol | 6 | Heme metabolism | 2 | 0.51 | 1.67 | 0.00 | 0.001 |
Total cholesterol | 6 | Cholesterol homeostasis | 2 | 0.45 | 1.33 | 0.04 | 1.00 |
Total cholesterol | 6 | Bile acid metabolism | 2 | -0.43 | -1.30 | 0.05 | 1.00 |
Total cholesterol | 6 | Bile acid metabolism | 6 | -0.49 | -1.45 | 0.00 | 0.30 |
LDL-cholesterol | 6 | Heme metabolism | 2 | 0.53 | 1.69 | 0.00 | 0.001* |
LDL- cholesterol | 6 | Heme metabolism | 6 | 0.36 | 1.20 | 0.04 | 1.00 |
Insulin | 2 | Oxidative phosphorylation | 4 | -0.41 | -1.30 | 0.01 | 0.50 |
Glycemia | 2 | Fatty acid metabolism | 2 | 0.44 | 1.30 | 0.03 | 1.00 |
Glycemia | 2 | Heme metabolism | 4 | -0.42 | -1.25 | 0.03 | 1.00 |
Glycemia | 2 | Oxidative phosphorylation | 4 | -0.39 | -1.20 | 0.04 | 1.00 |
Glycemia | 2 | Cholesterol homeostasis | 4 | 0.46 | 1.31 | 0.04 | 1.00 |
Glycemia | 2 | Glycolysis | 2 | 0.41 | 1.23 | 0.05 | 1.00 |
CCL5 | 2 | Oxidative phosphorylation | 4 | -0.38 | -1.23 | 0.04 | 1.00 |
Negative associations are indicated by the minus sign for the peak enrichment score (ES) or for the normalised peak enrichment score (NES). All associations with p ≤ 0.05 are shown;
* indicates significant correlations (padj < 0.10).
Abbreviations: CCL5, chemokine ligand 5; ES, enrichment score; LPS, lipopolysaccharide; NES, normalised peak enrichment score.