Table 1. Metabolic genesets enriched when genes are ranked by the correlation coefficient for change in gene expression and change in clinical parameter.

Clinical Parameter	Time clinical parameter assessed (h)	Geneset	Time gene expression assessed (h)	ES	NES	p	padj
LPS	2	Heme metabolism	2	0.42	1.24	0.01	0.72
LPS	2	Heme metabolism	6	0.41	1.28	0.03	1.00
LPS	6	Heme metabolism	2	0.42	1.39	0.00	0.04*
LPS	6	Heme metabolism	4	0.49	1.61	0.00	0.001*
LPS	6	Heme metabolism	6	0.38	1.22	0.04	1.00
Total cholesterol	6	Heme metabolism	2	0.51	1.67	0.00	0.001
Total cholesterol	6	Cholesterol homeostasis	2	0.45	1.33	0.04	1.00
Total cholesterol	6	Bile acid metabolism	2	-0.43	-1.30	0.05	1.00
Total cholesterol	6	Bile acid metabolism	6	-0.49	-1.45	0.00	0.30
LDL-cholesterol	6	Heme metabolism	2	0.53	1.69	0.00	0.001*
LDL- cholesterol	6	Heme metabolism	6	0.36	1.20	0.04	1.00
Insulin	2	Oxidative phosphorylation	4	-0.41	-1.30	0.01	0.50
Glycemia	2	Fatty acid metabolism	2	0.44	1.30	0.03	1.00
Glycemia	2	Heme metabolism	4	-0.42	-1.25	0.03	1.00
Glycemia	2	Oxidative phosphorylation	4	-0.39	-1.20	0.04	1.00
Glycemia	2	Cholesterol homeostasis	4	0.46	1.31	0.04	1.00
Glycemia	2	Glycolysis	2	0.41	1.23	0.05	1.00
CCL5	2	Oxidative phosphorylation	4	-0.38	-1.23	0.04	1.00

Negative associations are indicated by the minus sign for the peak enrichment score (ES) or for the normalised peak enrichment score (NES). All associations with p ≤ 0.05 are shown;

* indicates significant correlations (p_adj < 0.10).

Abbreviations: CCL5, chemokine ligand 5; ES, enrichment score; LPS, lipopolysaccharide; NES, normalised peak enrichment score.