| BIRC3 |
11q22 |
baculoviral IAP repeat containing 3 |
inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors |
AT-406 |
Ovarium cancern/ Acute myeloid Leukemia |
| PARP1 |
1q41-q42 |
poly (ADP-ribose) polymerase 1 |
repair of single-stranded DNA breaks |
olaparib |
Mammae and prostate cancer |
| PRKD3 |
2p21 |
protein kinase D3 |
Binding of diacylglycerol and phorbol esters |
momelotinib |
Myelofibrosis |
| RP56 / IMPG2 |
3q12.2-q12.3 |
interphotoreceptor matrix proteoglycan 2 |
organization of the interphoto-receptor matrix and may promote the growth |
PX-866 |
Non-small-cell lung cancer |
| WEE1 |
11p15.4 |
WEE1 G2 checkpoint kinase |
tyrosine kinase, catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase |
AZD1775 / MK1775 |
Solid tumors |
| ESR2 |
14q23.3 |
estrogen receptor 2 (ER beta) |
protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription |
tamoxifen |
mammacarcinoma |
| CKD1 |
10q21.2 |
Cyclin-dependent kinase 1 |
Ser/Thr protein kinase family and catalytic subunit protein kinase complex known as M-phase promoting factor |
Dinaciclib |
Chronic Lymfocytic Leukemia and multiple myeloma |
| PDK3 |
Xp22.11 |
pyruvate dehydrogenase kinase, isozyme 3 |
nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2
|
CPI-613 |
advanced hematologic malignancies |
| MAP3K1 |
5q11.2 |
mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase |
serine/threonine kinase and is part of transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway |
AZD8330 |
advanced malignancies |
