Table 3. Correlations between clinical, histological and molecular data and survival: Univariate and multivariate analysis.

		Total cohort		OII		OIII		OIIIw		OIIId
		EFS	OS	EFS	OS	EFS	OS	EFS	OS	EFS	OS
Histological grade	Low / High grade	NS	NS	/	/	/	/	/	/	/	/
Recurrence	No / Yes	0.0003*	<0.0001*	/	/	0.002	<0.0001	NS	0.01	0.001	0.0001
Age at diagnosis	< 50 / ≥ 50 years	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS
Sex	Male / Female	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS
Extent of surgery	Biopsy / Surgery	NS	NS	NS	0.003	NS	NS	NS	NS	NS	NS
Localization	Frontal / Other	0.004	0.05	NS	NS	0.04	NS	NS	NS	NS	NS
Postoperative treatment	No / Yes	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS
MVP	No / Yes	NS	NS	/	/	/	/	/	/	/	/
Necrosis	No / Yes	0.03	0.001	/	/	0.07	0.01	NS	NS	NS	NS
Calcifications	No / Yes	NS	0.03	NS	NS	NS	0.04	NS	NS	0.05	0.04
Mitoses /10 HPF	< 5 / ≥ 5	0.02	0.0004	NS	NS	0.06	0.003	0.01	0.001	0.008	0.001
MIB1	< 20 / ≥ 20%	0.04	0.003	NS	NS	0.04	0.004	0.02	0.002	0.002	<0.0001
INA	Negative / Positive	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS
p16	< 12 / ≥ 12%	NS	NS	NS	0.02	NS	NS	NS	NS	NS	NS
p16	Expression Yes / No	NS	NS	/	/	NS	NS	NS	NS	0.001	0.002
Cycline D1	< 37 / ≥ 37%	0.05	0.09	NS	NS	0.08	NS	NS	NS	NS	NS
Myc	< 35 / ≥ 35%	NS	NS	NS	NS	NS	NS	0.01	NS	NS	NS
Chr 9p	Deletion / None	<0.0001*	<0.0001*	/	/	0.0004	0.001	/	/	/	/

EFS: Event Free Survival, OS: Overall Survival, NS: Not significant, /: Not applicable,

*: also significant in multivariate analysis.