Table 1.
Tissue pathology
| Mouse # | Lymph Nodes (LN) | Spleen (Weight) | Mass/Tumor | Diagnosis |
|---|---|---|---|---|
| 414 | A lot of vasculature with perivascular lymphocyte accumulation; secondary follicles forming around perivascular lymphoid sheet | Preserved architecture (120mg) | None | Lymphoid hyperplasia |
| 424 | Many secondary follicles | Splenic architecture not disrupted, appears less well defined probably due to staining contrast (130 mg) | Liver mass - appears to be a normal liver tissue with few lymphoid aggregates | Lymphoid hyperplasia |
| 428 | Atypical morphology with loss of architecture: atypical cells, signs of apoptosis | Disrupted architecture - expansion of white pulp; large atypical lymphocytes with frequent mitosis and apoptosis (300 mg) | Liver mass - abscess within normal liver tissue; Mesenteric mass - lymphoma tissue, no architecture, increased cellularity, enlarged cells, mitosis; Adrenal mass - lymphoma tissue |
Multifocal Lymphoma |
| 429 | Tightly packed follicles increased in numbers, only some secondary follicles; plasmacytoid-like cells in between follicles | Disrupted architecture - loss of white/red pulp separation; presence of large atypical cells (430 mg) | Mesenteric mass - lymph node with B-cell nodules | B-cell lymphoma with nodular pattern |
| 437 | Lymphoid architecture effaced, secondary follicles present but not prominent; increased plasma cells but no atypical large cells present | Disrupted architecture - loss of white/red pulp separation; presence of large atypical cells, granulocytes (1000 mg) | Abdominal mass - squamous cyst with abscess | Suspicion of lymphoma |
| 444 | Normal | Normal appearance (180 mg) | None | |
| 445 | Small secondary follicles in mesenteric LN; prominent vasculature with perivascular lymphoid sheet - secondary follicles forming around vessels in cervical LN | Similar to glycogen storage disorder, no lymphoma-related changes (170 mg) | Regions of abnormally looking liver tissue contain dividing spindle-like cells and increased vasculature | Lymphoid hyperplasia; angiosarcoma in the liver |
| 470 | Effaced secondary follicles in the center of the LN | Normal appearance (80 mg) | None | Lymphoid hyperplasia |