Table 5.

Testing Characteristics of Blood and Stool Biomarkers to Distinguish Endoscopic Active Crohn’s From Endoscopic Inactive Crohn’s

	Cutoff	Sensitivity, %	Specificity, %	PPV, %	NPV, %	AUC (95% CI)
Neutrophil CD64 index	≥0.9	65	95	98	33	0.81 (0.73–0.89)
Soluble CD64	≥51 ng/mL	59	94	98	32	0.78 (0.68–0.88)
Neutrophil CD64 activity ratio	≥5.4	57	100	100	32	0.79 (0.70–0.88)
Fecal calprotectin	≥250 μg/g	84	88	98	44	0.90 (0.74–1.00)
C-reactive protein	≥0.5 mg/dL	73	100	100	32	0.86 (0.78–0.96)
Erythrocyte sedimentation rate	≥16 mm/h	74	100	100	36	0.91 (0.83–0.98)
Albumin	≥3.8 g/dL	77	85	97	38	0.86 (0.77–0.94)
Fecal calprotectin	≥50 μg/g	100	75	97	100	0.90 (0.74–1.00)

AUC = area under the curve; CI = confidence interval; NPV = negative predictive value; PPV = positive predictive value.