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. Author manuscript; available in PMC: 2018 Mar 1.
Published in final edited form as: J Am Chem Soc. 2018 Jan 22;140(4):1227–1230. doi: 10.1021/jacs.7b12579

Figure 3.

Figure 3

(A) Flow cytometry data showing CD8+ T-cell proliferation following incubation of pmel-1 splenocytes with the three types of SNAs at 10 pM concentration. (B) Dose–response curve of SNA treatment on T-cell proliferation. Average and standard deviation for three replicates are shown for each point (see Figure S9 for additional replicates). The curves are three-parameter dose–response fits with a shaded 95% confidence interval of the fit. (C) Secreted TNF-α, IFN-γ, Granzyme B, and IL-6 were quantified by ELISA at a 10 pM treatment concentration, ****p < 0.0001.