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. Author manuscript; available in PMC: 2018 Apr 12.
Published in final edited form as: Nature. 2017 Oct 12;550(7677):529–533. doi: 10.1038/nature24269

Extended Data Figure 1. Multiple models have been proposed to explain the cell of origin for BE.

Extended Data Figure 1

a, Transdifferentiation of the stratified squamous oesophageal epithelium into Barrett’s epithelium. b, Transdifferentiation of circulating bone marrow cells into Barrett’s epithelium. c, Expansion of the oesophageal submucosal gland leads to BE. d, Stem/progenitor cells (Lgr5+) in the cardia mucosa differentiate into BE. e, Expansion of the quiescent residual embryonic cells (RECs) at the SCJ leads to BE formation. Note that none of the studies recapitulates the pathological changes characteristically associated with BE in humans, e.g. presence of intestinal goblet cells.

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