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. Author manuscript; available in PMC: 2018 Apr 12.
Published in final edited form as: Nature. 2017 Oct 12;550(7677):529–533. doi: 10.1038/nature24269

Extended Data Figure 10. Intestinal metaplasia develops in air-liquid culture of the transitional (p63+ KRT7+) but not the squamous (p63+ KRT7−) basal progenitor cells upon CDX2 expression.

Extended Data Figure 10

a, Schematic depicts Doxycycline-induced CDX2 expression. b, Intestinal metaplasia occurs in Dox-treated transitional (p63+ KRT7+) but not squamous basal (p63+ KRT7−) progenitor cells. Note that p63+ KRT7− basal cells generate a thick keratin layer in the ALI culture, and the differentiated cells express Loricrin. n=5 per group. Scale bar, 20 μm.