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. Author manuscript; available in PMC: 2018 Apr 12.
Published in final edited form as: Nature. 2017 Oct 12;550(7677):529–533. doi: 10.1038/nature24269

Extended Data Figure 8. Intestinal metaplasia is maintained even after withdrawal of Dox in Krt5-rtTA;otet-CDX2-T2A-mCherry mutants.

Extended Data Figure 8

a, Severe metaplasia develops at the SCJ of mutants that have been treated with Dox for the first 13weeks and chased for another 11weeks. n=3 per group. b, The metaplastic cells remain at the SCJ even after withdrawal of Dox containing water. The metaplastic cells express KRT7 and KRT8. Note that mCherry which indicates CDX2 expression is not detected. n=3 per group. c, Metaplastic cells maintain AGR2 and Villin1 expression. n=3 per group. Scale bar, 20 μm.

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