Extended Data Figure 9. Ectopic CDX2 expression promotes intestinal metaplasia of the transitional epithelium in Krt7-CreER; R26rtTA; otet-CDX2-T2A-mCherry mutants.
a, Schematic shows induction of CDX2 overexpression by combined treatment of Tamoxifen and Doxycycline. b, 30-day CDX2 expression drives the differentiation of the transitional basal cells into intestinal-like epithelium including goblet cells in Krt7-CreER; R26rtTA; otet-CDX2-T2A-mCherry mice. n=3 per group. c, 90-day CDX2 overexpression leads to prominent intestinal metaplasia of the transitional basal progenitor cells as indicated by intestinal markers. n=4 per group. Abbreviation: Sq, stratified squamous epithelium; Co, columnar epithelium. Scale bar, 20 μm.