Table 2.
Lewy body symptoms by final neuropathological diagnosis
| AD | DLB | Mixed AD+DLB | ||
|---|---|---|---|---|
| N = 19 | N = 18 | N = 22 | ||
| Core and suggestive symptoms | ||||
| Cognitive fluctuations ever | 5 (26%) | 9 (50%) | 8 (36%) | X = 2.23, df = 2, P = 0.33 |
| Complex visual hallucinations at any time | 3 (16%) | 17 (94%) | 11 (50%) | X = 23.0, df = 2, P < 0.001 |
| AD vs mixed, X = 5.31, df = 1, P = 0.02 | ||||
| DLB vs mixed, X = 9.30, df = 1, P < 0.01 | ||||
| Complex visual hallucinations at baseline | 1 (5%) | 12 (67%) | 3 (14%) | X = 20.86, df = 2, P < 0.01 |
| AD vs mixed, X = 0.81, df = 1, P = 0.36 | ||||
| DLB vs mixed, X = 11.88, df = 1, P < 0.01 | ||||
| Complex visual hallucinations emerging later | 2 (11%) | 5 (28%) | 8 (36%) | X = 3.67, df = 2, P = 0.16 |
| AD vs mixed, X = 3.69, df = 1, P = 0.055 | ||||
| DLB vs mixed, X = 0.33, df = 1, P = 0.564 | ||||
| Parkinsonism at any time | 4 (21%) | 12 (67%) | 10 (45%) | X = 7.83, df = 2, P = 0.02 |
| AD vs mixed, X = 2.7, df = 1, P = 0.1 | ||||
| DLB vs mixed, X = 1.80, df = 1, P = 0.15 | ||||
| Parkinsonism at baseline | 1 (5%) | 8 (44%) | 5 (23%) | X = 7.86, df = 2, P = 0.02 |
| AD vs mixed, X = 2.49, df = 1, P = 0.13 | ||||
| DLB vs mixed, X = 1.36, df = 1, P = 0.2 | ||||
| Parkinsonism emerging later | 3 (16%) | 4 (22%) | 5 (23%) | X = 0.36, df = 2, P = 0.84 |
| RBD at any time | 4 (21%) | 12 (67%) | 7 (32%) | X = 7.83, df = 2, P = 0.02 |
| AD vs mixed, X = 0.60, df = 1, P = 0.34 | ||||
| DLB vs mixed, X = 4.82, df = 1, P = 0.03 | ||||
| RBD at baseline | 1 (5%) | 6 (33%) | 0 (0%) | X = 11.69, df = 2, P < 0.01 |
| AD vs mixed, X = 1.19, df = 1, P = 0.46 | ||||
| DLB vs mixed, X = 8.63, df = 1, P < 0.01 | ||||
| RBD emerging later | 3 (16%) | 6 (33%) | 7 (32%) | X = 1.83, df = 2, P = 0.4 |
| Neuroleptic sensitivity at any time | 3 (16%) | 2 (11%) | 3 (14%) | X = 0.17, df = 2, P = 0.92 |
| Exposed to use of neuroleptic | 7 (37%) | 9 (50%) | 12 (55%) | X = 1.35, df = 2, P = 0.51 |
| Supportive symptoms | ||||
| Falls at any time | 7 (37%) | 9 (50%) | 11 (50%) | X = 0.90, df = 2, P = 0.64 |
| Other hallucinations at any time | 1 (5%) | 2 (11%) | 5 (23%) | X = 2.79, df = 2, P = 0.25 |
| Delusions at any time | 3 (16%) | 7 (39%) | 6 (27%) | X = 2.79, df = 2, P = 0.25 |
| Depression at any time | 10 (53%) | 9 (50%) | 6 (27%) | X = 3.30, df = 2, P = 0.19 |
| Anxiety at any time | 11 (58%) | 9 (50%) | 11 (50%) | X = 0.32, df = 2, P = 0.85 |
| Behavioural disturbance at any time | 11 (58%) | 8 (44%) | 12 (55%) | X = 0.73, df = 2, P = 0.70 |
AD Alzheimer’s disease, DLB dementia with Lewy bodies, RBD REM sleep behaviour disorder