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. Author manuscript; available in PMC: 2018 Mar 1.
Published in final edited form as: Adv Healthc Mater. 2017 Jun 6;6(17):10.1002/adhm.201700232. doi: 10.1002/adhm.201700232

Figure 5.

Figure 5

The Hierarchical Organization of Bone. On the left, the gross anatomical structure of calvarial bone is depicted. Calvarial bone consists of cortical bone (inner and outer tables) separated by the cancellous or trabecular bone (diploe). Cortical bone consists of osteons consisting of osteocytes within lacunae arranged regularly within the lamellae of collagen fibers surrounding the central canal. Cancellous bone consists of a more irregular organization of lacunae, osteocytes, and canaliculi enclosing bone marrow. Collagen fibers that comprise the lamellae are further broken down into collagen proteins arranged with calcium phosphate mineral.