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. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Biomaterials. 2018 Feb 3;161:216–227. doi: 10.1016/j.biomaterials.2018.01.040

Fig. 2. Delivery of therapeutic growth factors to potentiate bone regeneration.

Fig. 2

A) Gelatin microspheres can be designed to sequester BMP2 and can be used as a minimally-invasive method of delivering growth factor to bone wounds. B) Design of microspheres to be preferentially degraded by inflammatory macrophages allows delivery of BMP2 during the late inflammation phase of healing, and promotes progression to endochondral ossification, thereby preventing delayed healing.