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. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Biomaterials. 2018 Feb 3;161:216–227. doi: 10.1016/j.biomaterials.2018.01.040

Fig. 3. Morphology, genipin crosslinking chemistry and enzymatic degradation of gelatin microspheres.

Fig. 3

A) Confocal image of microspheres show spherical morphology. B) Histogram showing the size distribution of crosslinked gelatin microspheres (inset shows the box plot of the size distribution). C) Genipin is used to crosslink lysine residues in gelatin via a two-step process. D) The degradation rate of crosslinked microspheres increased with an increase in collagenase concentration. E) Enzymatic degradation of the microspheres caused an initial burst release followed by sustained release of the remainder of the payload.