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. 2018 Jan;110(1):44–51. doi: 10.5935/abc.20180008

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This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Melatonin promoted activation of ERK1 in H9C2 cells against H/R. H9C2 cells incubated in normal condition or in simulated H/R condition, in simulated H/R condition plus pretreatment with melatonin, or in simulated H/R condition plus pretreatment with melatonin and PD98059 (ERK1 inhibitor).The expression levels of phosphorylated ERK1 (p-ERK1) were evaluated by Western blotting (A) and were quantitatively analyzed (B). All values are presented as the mean±SD. n = 3. SSp < 0.01 vs. H/R group; #p < 0.05 vs. H/R+Mel group.(Control: control group; H/R:H/R group; H/R+mel: H/R+ melatonin group; H/R+mel+PD: H/R+ melatonin+PD98059 group)